Statistical optimization of sustained release venlafaxine HCl wax matrix tablet

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Formulation Design, Optimization and Pharmacodynamic Evaluation of Sustained Release Mucoadhesive Microcapsules of Venlafaxine HCl

The objective of present research work was to design and characterize the venlafaxine HCl-loaded sodium alginate-based mucoadhesive microcapsules by ionic gelation technique using HPMC K100M as mucoadhesive polymer. The Placket-Burman Design was applied for preliminary screening of the formulations and systematic optimization by using Box-Behnken Design. The prepared microcapsules were characte...

متن کامل

Wax-Matrix Sustained-Release Nicotinic Acid

Today we have more options than ever for the pharmacological management of hyperlipemia. Some of the newer agents have unprecedented potency in lowering LDL cholesterol while others may be better at reducing triglycerides or improving HDL. Keeping track of which drugs are best for which lipid problems can be a challenge in the everyday practice of medicine. I offer here a simple rationale for s...

متن کامل

Formulation and optimization of sustained release matrix tablet of metformin HCl 500 mg using response surface methodology.

The aim of the current study was to design an oral sustained release matrix tablet of metformin HCl and to optimize the drug release profile using response surface methodology. Tablets were prepared by non-aqueous wet granulation method using HPMC K 15M as matrix forming polymer. A central composite design for 2 factors at 3 levels each was employed to systematically optimize drug release profi...

متن کامل

Modulation of Venlafaxine Hydrochloride Release from Press Coated Matrix Tablet

The aim of present study was to prepare novel modified release press coated tablets of venlafaxine hydrochloride. Hydroxypropylmethylcellulose K4M and hydroxypropylmethylcellulose K100M were used as release modifier in core and coat, respectively. A 3(2) full factorial design was adopted in the optimization study. The drug to polymer ratio in core and coat were chosen as independent variables. ...

متن کامل

Statistical Optimization of Controlled Porosity Osmotic Tablet of Milnacipran HCl

Aim: The objective of this study was to identify critical formulation parameters affecting the drug release from controlled porosity osmotic tablet of milnacipran hydrochloride employing the concept of design of experiments. Materials and Methods: The optimized amount of ethocel (X1) and mannitol (X2) in core and percentage of sorbitol (X3) in coat were determined employing a three-factor, thre...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Indian Journal of Pharmaceutical Sciences

سال: 2008

ISSN: 0250-474X

DOI: 10.4103/0250-474x.44596